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(ii) Activate immune dysregulation through PAR2/NF-B and ERK1/2-Ets1 signaling pathways, promoting oral mucosal pathogenesis.) (Right Panel: Probiotic Intervention) Probiotics counter disease progression by: (i) Suppressing pro-inflammatory signaling (NF-B, TNF, IL-17) to reduce inflammatory infiltration;(ii) Preserving epithelial barrier integrity via prevention of tight junction protein degradation (e.g., by reducing LPS burden)

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Various adjuvants may be used to increase the immunological response, depending on the host species, and include but are not limited to, Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanins, dinitrophenol, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and nd ed