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The 5-LOX and 12/15-LOX pathways regulate synaptic pruning and phagocytosis by microglia, affecting neurodevelopment

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And then I talked with my team and they're like, Dave, this is a very big difference from the supplements, the nootropics in the coffee and the protein bars and all that. Let's not. So I actually started a separate company

High (variant is assumed to have disruptive impact in the protein: stop codon gained and loss of function), low (harmless or unlikely to change protein behavior: synonymous codon), moderate (non-disruptive variant that might alter protein effectiveness: missense codon and inframe codon loss) and modifier (non-coding variants or variants affecting non-coding genes: exon variant and downstream gene variant) are parameters used by SnpEff to correlate SNPs and their putative impact on protein functioning