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In a rat model of DOX-induced cardiotoxicity, it has been unequivocally demonstrated that DOX induces the production of ROS and transforming growth factor-beta (TGF-), thereby promoting the transformation of cardiac fibroblasts into myofibroblasts (Tian et al., 2024)

Schaafhausen MK, Yang WJ, Centanin L, Wittbrodt J, Bosserhoff A, Fischer A, Schartl M, Meierjohann S (2013) Tumor angiogenesis is caused by single melanoma cells in a manner dependent on reactive oxygen species and NF-b

Severe tears can cause subtle but noticeable changes in knee alignment or shape, with the joint appearing slightly "off" compared to the uninjured side when viewed from the front or side

Chronic Insomnia : A long-term condition, persisting for months or years, which may arise independently or as a symptom of other health issues