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J Biomed Sci 25(1):111 Murray BO, Dawson RA, Alsharaf LM, Winter JA (2020) Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents

Note: B vitamins include thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate/folic acid (B9), and cobalamin (B12)

Studies have shown that gp43 and peptides derived from this glycoprotein have the ability to avoid phagocytosis and are also considered as evasion mechanisms of this fungus (Flavia Popi et al., 2002

Since the 1990s, clinical research has been carried out by a study group on the Ministry of Health, Labour and Welfare, suggested that ultrahigh-dose mecobalamin, which is respectively 50 and 100 times the approved dosage of Methycobal, could have a clinical effect in ALS, and Eisai then conducted the Phase II/III clinical trial (Study 761) from 2006