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Ropinirole hydrochloride for amyotrophic lateral sclerosis: a single-center, randomized feasibility, double-blind, placebo-controlled trial

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Wang T., Ashrafi A., Modareszadeh P., Deese A

Recent studies have demonstrated that artemisinin-type drugs effectively impede receptor-mediated signaling cascades by inhibiting an array of signaling pathways, including IL-1, TNF-, 3-integrin, RANKL, Toll-like receptor, and growth factor receptor pathways, and by modulating crucial signaling molecules such as JNK, PI3K, AKT, ERK, and MAPK, among others