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Evidence also suggests that B12 deficiency can cause inflammation and damage to blood vessels, as well as oxidative stress, which combined can interrupt normal blood flow to the feet (Spence, 2016)

Effect of APE on pro-inflammatory and anti-inflammatory cytokine secretion in LPS-stimulated RAW264.7 cells The effects of APE on the secretion levels of pro-inflammatory cytokines TNF- and IL-6, as well as the anti-inflammatory cytokine IL-10, in LPS-stimulated RAW264.7 macrophage cell were examined