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Data availability The datasets generated and/or analysed during the current study are not publicly available as per the rules and regulations of the Research Center for Biochemistry and Nutrition in Metabolic Diseases at the Kashan University of Medical Science but are available upon reasonable request from the corresponding author

These findings support the notion that targeting lipid metabolic dysfunction may offer a feasible strategy to mitigate CaOx crystal-induced kidney damage

Cardiometabolic diseases (e.g., heart failure, T2D, hypertension) accelerate frailty, and conversely, frailty predicts worse cardiovascular and cognitive outcomes [38]

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