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Cell Mol Life Sci

Synaptogenesis, the formation of new synapses, depends heavily on BDNF signaling through the ERK pathway

Although it was originally characterized as a metastasis suppressor gene, its most well-characterized role is in stimulating the secretion of GnRH from GnRH neurons, in turn leading to gonadotrophin production from pituitary gonadotrophs

Malar DS, Thitilertdecha P, Ruckvongacheep KS et al (2023) Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders