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doi: 10.1007/s00259-012-2110-3 317 PfallerM

5 Conclusions and perspectives HO-1 plays a dual role in atherosclerosis, particularly in the regulation of ferroptosis, which presents both therapeutic opportunities and challenges ( HO-1 can exert both beneficial and harmful effects at different pathological stages, making the regulation of its temporal and spatial expression crucial

The PI3K/Akt/mTOR pathway 20 along with the p38 MAPK, ERK1/2 and STAT3 signaling axis 21 have been implicated in controlling glycolytic phenotypes of the tol-DC, but the role for AMPK in both immunologic and tol-DC biology is largely understudied, and the precise role of mTOR/AMPK balance is controversial 4,13

Asian Pac J Health Sci