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The exceptions that prove the rule-a historical view of bedaquiline susceptibility

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Metallomics 7 , 202211 (2015)

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GHK-Cu moduliert die extrazellulare Matrix, TB-500 das Zytoskelett und die Zellmigration, BPC-157 vaskulaere und entzuendungsrelevante Signalwege

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(2015), BioMed Research International 2015:648108, PubMed 26236730 Statystyki z literatury badawczej Odkryty przez Lorena Pickarta w ludzkim osoczu krwi w roku 1973 , jako czynnik zwikszajcy dugowieczno hodowanych komrek wtroby Najmniejszy peptyd o aktywnoci farmakologicznej: 3 aminokwasy (Gly-His-Lys) + jeden jon Cu Masa czsteczkowa: 402 Da Nazwa INCI w kosmetyce UE: Copper Tripeptide-1 (zarejestrowany w bazie CosIng EU Commission) Modulacja ekspresji genw: 4 000 ludzkich genw (zbir danych Connectivity Map, Pickart 2015) Stenie w osoczu u zdrowego czowieka spada z ~200 ng/mL w wieku 20 lat do ~80 ng/mL w wieku 60 lat (62 % spadku) Najlepiej zbadana bioaktywno: proliferacja fibroblastw , synteza kolagenu I/III , aktywno antyoksydacyjna (upregulacja SOD) rda referencyjne (PubMed) Pickart L., Vasquez-Soltero JM., Margolina A

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