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Some of them showed a significant decrease in the ascorbate concentration in the serum and plasma of individuals with periodontitis, 27 , 45 depending on the severity of periodontopathy

10.1002/1873-3468.12964 FEBS

Vitamin B 1 deficiency [14] Causes Pathophysiology Thiamine deficiency impaired glucose breakdown ATP depletion tissue damage that primarily affects highly aerobic tissues (e.g., brain, heart) High-dose glucose infusions lead to increased ATP depletion, which can trigger Wernicke encephalopathy

Afterward, cell phenotype was examined by testing their senescence level and cartilage formation capacity