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Mechanistically, PSAT1 activates STAT3 signaling pathway through its interactiopm with IQGAP1, and this effect remains even in the presence of catalytically inactive PSAT1 mutants [126] (Fig

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Nevertheless, BSCB disruption in turn exacerbates inflammatory reactions, resulting in irreversible spinal cord damage (Ding et al., 2010)

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