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Your health care provider needs to know if you have any of these conditions: kidney disease

The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

Among these, Asian countries (n = 4), European countries (n = 3), North American countries (n = 1), African countries (n = 1), and South American countries (n = 1) dominate the top 10 regions based on the total number of publications (Table 1)

doi: 10.3389/fnins.2014.00447 217 WuX.ChiF.WangB.LiuS.WangF.WangJ.et al