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FFA treatment has been linked to increased survival rates in human studies and in vivo models [57]

These varying observations highlight the critical distinction between enzyme concentration and actual catalytic activity, as evidenced in other inflammatory conditions where plasma SOD1 concentration increased while total activity remained unchanged (Sciskalska et al., 2020)

Lieberman, A

Inhibition of protease activity has been shown to suppress tumor metastasis, with studies demonstrating that targeting the PI3K/Akt and JNK1/2 signaling pathways reduces MMP 2, MMP 9, urokinase plasminogen activator (u-PA), NF-B, and AP-1 mRNA and protein expression in tumor cells, thereby impeding tumor invasion and metastasis