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Recently, the yeast Scheffersomyces stipitis has been shown to produce folate at concentrations of 3.4 mg/L under optimized cultivation conditions, the highest value obtained during fermentation in microorganisms with natural production ability 629,630

Moreover, in vitro experiments with HCC cells, demonstrated that mitochondrial fission significantly promoted the reprogramming of focal adhesion dynamics and lamellipodia formation mainly, by activating the CA 2+/ CaMKII/ERK/FAK pathway, which was associated with a greater capacity for migration and invasion (123, 125)

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