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1 After nerve injuries occur, various symptoms, such as muscle atrophy and neuropathic pain, affect activities of daily living (ADL) and the mental condition

Key characteristics: 28 to 90 day beyond-use date from preparation (varies by pharmacy) May or may not contain preservatives Multi-dose vials requiring multiple punctures Potency can vary between batches Different pharmacies produce different quality levels Storage requirements may differ from brand-name The variability between compounding pharmacies is significant

Dose: either: 1000 g per day (it is recommended divided into two smaller doses of 500 g, as this results in a higher absorption rate see below) or: 5000 g per day

Methods: In this cross-sectional study we compared plasma vitamin B12, methylmalonic acid, and homocysteine levels between 50 RA patients treated with methotrexate and folic acid and 49 RA patients using other DMARDs