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Isaac JT, Nicoll RA, Malenka RC (1995)

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For example, Luteolin modulated intestinal flora (decreased F/B ratio, elevated Bifidobacterium , Lactobacillus ) against liver fatty lesions in rats (Liu, 2022), while BBR successful in boosting Akkermansia abundance, it also enhanced intestinal tight junction protein expression and colonic mucus layer thickness, reduced HFD-induced metabolic endotoxemia and decreased expression of pro-inflammatory factors and chemokines (Zhu et al., 2018)

As the level of toxic burden grows, the liver gets more sluggish and overwhelmed and unable to neutralize hazardous chemicals in our bloodstream