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These metabolites also affect epigenetic and cellular mechanisms involved in tumor suppression and metabolic health, positioning SCFAs as key mediators in probiotic-induced health benefits (175177)

BNIP3 and NIX act as mitophagy receptors that can tether the isolation membrane to mitochondria (Yamashita et al., 2024)

Cell culture Human HCC cell lines MHCC97H, HepG2 and PCa cell line DU145 were cultured in high-glucose DMEM complete medium with 10% fetal bovine serum (FBS