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Pivotal research by Rudman and colleagues found that six months of GH in older men increased lean body mass and reduced fat mass versus placebo [7] , and long-term studies in adults with GH deficiency show sustained body-composition benefits with maintenance dosing [8]

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Abstract Strategies for the biological repair of intervertebral discs derive from the premise that disc degeneration results from impaired cellular activity and, therefore, that these structures can be induced to regenerate by implanting active cells or providing factors that restore normal cellular activity