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MPTP, which selectively damages nigrostriatal dopaminergic neurons through its metabolite MPP + , is a commonly used model for studying the pathological mechanisms of PD

Lifestyle-based strategies, including caloric restriction, antioxidant-rich diets, regular physical activity, and adequate sleep, help maintain metabolic balance, reduce oxidative stress, and enhance autophagic turnover, thereby supporting circadian synchrony and systemic homeostasis [24,25]

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If your impairments don't exactly match the criteria of an impairment listing, the medical consultant must consider whether you have an impairment that's equivalent to a similar impairment, in terms of severity