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American association of clinical endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity

In Phase II results , adults taking the two highest doses lost about 16% more body weight than those on placebo after 44 weeks

In my clinical experience, patients with tendinopathy lasting 6-24 months often report: Significant pain reduction by week 2-3 Improved load tolerance during physical therapy by week 4-6 Return to prior activity levels (with appropriate rehab) by week 10-14 Ligament Injuries Partial ligament tears (ankle sprains, knee MCL/LCL sprains, wrist sprains) often leave residual instability and chronic pain

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