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In certain type of cancer, it may be an unsuccessful strategy, since many cancer cells upon cysteine scarcity or the inhibition of cys(e)ine transport can upregulate TSP for endogenous cysteine production (137, 138)

Engineering 2D multienzyme-mimicking pyroptosis inducers for ultrasound-augmented catalytic tumor nanotherapy

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However, the association between cysteine transport and the overexpression of these transporters in cancer metabolic remodelling has not yet been established, as these transporters are not specific for cysteine and so the focus of most studies is the transport of other amino acids (e.g