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Zinc ions play a critical role in several metabolic reactions and, when combined with copper, form part of the functional group of key enzymes, such as Cu-Zn SOD and endothelial NOS, which functions to prevent atherosclerosis (153)

In parallel, they exert significant immunomodulatory effects: polysaccharides stimulate the immune system's antitumor response by activating macrophages, T lymphocytes, natural killer cells, and dendritic cells, and by promoting the release of cytokines such as TNF-, IFN-, and IL-2 (134)

Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats

*Correspondence: Vishwanath Venketaraman, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Infectious Diseases, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers