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Fibro-proliferative bile ductular cells often extend into the hepatic parenchyma, bridging adjacent portal areas and leading to biliary cirrhosis without renewal of bile ducts [94]

Its unique research profile makes DSIP useful for studies focused on neuropeptide biology, signaling network characterization, and mechanistic analysis of peptide-mediated regulatory processes.

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Together, these mechanisms create comprehensive research tools for investigating fundamental questions about musculoskeletal tissue engineering, biomechanical property optimization, and regenerative capacity in laboratory models of tendon, ligament, muscle, and bone repair