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Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide

Met-supplemented rice proteins (additional supplementation with 0.5, 1.0, and 1.5-fold of Met) can enhance GSH synthesis to augment endogenous antioxidant activity in rats 11

Studies have combined auranofin with cisplatin and ATR/AKT inhibitors to selectively elevate ROS levels in cancer cells and induce oxidative DNA damage [221,222,223] (Table 4)