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Toll-like receptor 9 can be activated by endogenous mitochondrial DNA to induce podocyte apoptosis

To test this, we inhibited the cysteine/glutamate antiporter System Xc - using Imidazole Ketone Erastin (IKE), thereby limiting substrate availability for GSH synthesis ( Figure 6H )

276 In a controlled trial in 40 healthy subjects aged 5070 years old, taking a mixed berry drink for five weeks improved cardiovascular risk markers as well as performance on memory tests compared with placebo