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Research has characterised PT-141 as a direct MT-II derivative produced by C-terminal amide hydrolysis , documenting preserved cyclic heptapeptide structure, maintained MC3R/MC4R pro-sexual activity, and reduced MC1R-mediated pigmentation activity relative to MT-II

52 Oral ingestion of forskolin stimulates chloride and water secretion into the intestinal lumen, reduces water reabsorption, and causes decreased smooth muscle relaxation and cAMP modulation in the intestines, contributing to diarrhea