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Simultaneously, catalytically produced hydrogen peroxide (H 2 O 2 ) activates the protein transient receptor potential melastatin 2 (TRPM2) ion channel, promotes calcium influx, activates macrophages, and induces systemic immune response (Fig

The similarity of some aspects of the inhibition of the mitochondrial transporter with those previously found for the plasma membrane OCTN2 transporter, which however were not described at the molecular level [19], indicates that the substrate binding sites should have some similar properties, in spite of the very different primary structures and affinity for substrates of the two proteins

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Hormetic Effects in Food Food represents a rich and diverse source of hormetic compounds, or hormetins, capable of inducing beneficial adaptive responses in the body