Propofol is a dose-dependent sedative-hypnotic with agonism of GABA receptors through a site different from that of benzodiazepines, and inhibition of NMDA subtype of glutamate receptor
K.BarrM
Kidney Use with Caution GTLIVE 600MG INJECTION should be used with caution in patients with kidney problems such as acute renal failure
Introduction Tuberculosis (TB) is a chronic infectious disease caused by an obligate pathogen, Mycobacterium tuberculosis (Mtb), in humans ( in vitro drug resistance to not only INH and RIF, but also all fluoroquinolones and at least one injectable aminoglycoside ( The presence of a mycobacterial population with more than one bacterial phenotype has been observed in patients with TB, as indicated by bacterial populations with varying growth dynamics in sputum samples ( Mycobacterial Persisters Adapt to Stresses in the Host and Exhibit Antibiotic Tolerance Antibiotic Tolerance Host-related stresses, such as hypoxia, acidic conditions, nutrient starvation, oxidative stress, and cytokine responses, alter the metabolic state of pathogens and eventually induces a drug-tolerant phenotype termed persister ( The mechanism of antibiotic tolerance through the formation of persisters in response to a variety of stresses, including nutrient deprivation, oxidative stress, acidic environment, osmotic conditions, and host immune-mediated stresses, has been described in many pathogenic bacteria, including Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , and Mtb ( Mtb Adapts to Host-Mediated Stresses Through Metabolic Regulation Regulation of Transcription Factors Mtb encounters various stresses, such as acidic pH, oxidative stress, hypoxia, nutrient deprivation, and cytokine-mediated effectors, during infection
