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IL-23 is a pivotal proinflammatory cytokine whose elevated expression enhances the inflammatory milieu and promotes the release of IL-17 A and IL-22 by Th17 and T cells, thereby establishing a positive feedback loop that accelerates psoriatic lesion development [6, 57, 58].] In imiquimod (IMQ)-induced murine models of psoriasis, CGRP expression in the dorsal root ganglia is rapidly upregulated following IMQ application and is closely associated with characteristic psoriatic inflammation [49, 54, 59]

Even the blueberries are upgraded