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The human body can produce it from amino acids found in protein-rich food, but production reduces if someone is on a calorie deficit, on a vegan or vegetarian diet or under intense physical stress

While it is the overall diet or whole foods that mediate the impact on gut microbial composition, targeted effects might also be achieved through selected dietary-derived metabolites that are substrates for certain microbial species, an approach that underpins prebiotic development

Most of the evidence present in the literature comes from case-based clinical observations