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By modulating p38 MAPK signaling, CBD can indirectly influence other pro-tumorigenic pathways, such as STAT3 and TGF-, contributing to a broader anticancer effect [209,210]

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Heat stress leads to an increase in the level of reactive oxygen species (ROS) and a simultaneous decrease in ROS scavenger activity, leading to biomolecul damage and apoptosis (Guan et al., 2013)