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Description

Mol Cell Biochem 480 , 1941 (2025)

an updated review

10.1016/0003-2697(92)90122-n 24 KakkarP.DasB.ViswanathanP

Quinolinic acid (quinurenine metabolites) is a precursor of nicotinamide adenine dinucleotide (NAD) that has neurotoxic properties through its binding to the postsynaptic N-methyl-D-aspartate (NMDA) receptor, followed by a sustained influx of Ca2+ leading to increased oxidative and nitrosative stress (197, 198)