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While MTHFR can impact folate processing, which is crucial during pregnancy, managing folate intake through diet and/or supplements can reduce the risk of complications

Unlike Phase 1, which relies primarily on enzyme activity, Phase 2 conjugation requires an adequate and ongoing supply of specific substrates to safely neutralize activated metabolites

Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)