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In IBD, the PERK-C/EBP homologous protein (CHOP) axis plays a key role in linking ERS to mucosal inflammation (81)

(3) Inflammation and Immune Dysregulation An increasing body of evidence supports the cytokine hypothesis of depression, proposing that neuroinflammation plays a significant role in the development of MDD

They rarely, if ever, occur as an isolated symptom of liver dysfunction

In vitro and in vivo studies have evaluated the biological functions of GHR in breast cancer by silencing GHR and showed that GHR reduction leads to the inhibition of cell proliferation, the cell-cycle arrest in G1-S phase transition, tumor growth, and cell apoptosis induction of breast cancer cell lines, speculating these effects might be due to the inhibition of the Raf/MEK/ERK signaling pathway (Zhu et al., 2020)