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H.MortezapourE.et al, 2020b

Peripheral-to-central signaling may also occur via multiple complementary mechanisms, including cytokine transport systems, neural pathways, and immunemetabolic signaling cascades [1]

Additionally, analyses of the gut microbiota in PD patients revealed dysbiosis characterized by a reduction of bacteria producing short-chain fatty acid which are crucial for maintaining the barrier integrity of the intestines 44,45

Plus, as dietary supplements, they skirt the level of Food and Drug Administration approval required for over-the-counter and prescription meds, so they can be contaminated or make false claims about what they contain