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Lpez IP, Pieiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG

Nat Cell Biol 2016;18:886-96

Gpx8 knockout in mice severely exacerbated DSS-colitis and reduced gut microbiome diversity ( Gpx8 / mice post-DSS treatment expressed higher levels of pro-inflammtory cytokines (IL-1 and IL-6) and adoptive transfer of Gpx8 -deficient macrophages into mice prior to DSS treatment resulted in an exacerbated colitis phenotype indicating a protective role for GPx8 in macrophages during experimental colitis ( Gpx8 / mice was found to be dependent on its action on caspase-11