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Emerging evidence suggests that microglia, as key neuroimmune modulators within the CNS, influence the incidence and progression of cardiovascular diseases, including hypertension, myocardial infarction, and ischemia/reperfusion injury, through mechanisms potentially linked to altered autonomic nervous system activity (Wang M

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Chronic inflammation may lead to inflammatory and other health conditions, in fact, it is one of the root causes of most modern-day diseases and age-related conditions

At the molecular level, the circadian clock functions through a transcription-translation feedback loop (TTFL), with about 24 h periodicity [6]