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Reported approaches include LDM (Wellcomet, Germany) ultrasound for the mechanical dispersion of tissue and trapped blood components, PICO laser for pigment fragmentation, radiofrequency (RF) to soften the scaffoldtissue complex, long-pulsed Nd:YAG for targeting residual pigment molecules, IPL for vascular and pigment clearance, and an enzymatic strategy

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Vitamin D, in particular, not only alleviates OS but also exerts therapeutic effects by regulating key nodes in hormonal signaling pathways

More serious side effects, such as allergic reactions or nerve damage, can occur in rare cases