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As further described below, anti-cancer agents encompass biotherapeutic anti-cancer agents (e.g., interferons, cytokines (e.g., tumor necrosis factor, interferon alpha, interferon gamma, etc.), vaccines, hematopoietic growth factors, monoclonal serum therapies, immunostimulants and/or immunomodulators (e.g., IL-1, 2, 4, 6 and/or 12), immune cell growth factors (e.g., GM-CSF), and antibodies (e.g., trastuzumab (trastuzumab), T-DM1, bevacizumab (bevacizumab), cetuximab (cetuximab), panitumumab (panitumumab), rituximab (rituximab), tositumomab (tositumomab), etc.), as well as chemotherapeutic agents

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