l-glutathione experience Glutone 1000 Setria Effervescent Tablets Face Fresh L-Glutathione Ampoule makes

Rhee CK, Chau NQ, Yunus F, Matsunaga K, Perng DW, on behalf the CAotA

(55) further demonstrated that in models of PD and other neurodegenerative diseases, EGCG exerts neuroprotective effects via NF-B signaling inhibition by blocking IB phosphorylation and suppressing p65 nuclear translocation, thus downregulating pro-inflammatory cytokines such as TNF- and IL-1 and reducing dopaminergic neuronal loss and motor dysfunction

The degeneration of dopaminergic neurons affects motor symptoms and non-motor functions

In a mouse PD model induced by -synuclein preformed fibrils (PFFs), EGCG treatment decreased TNF- and IL-6 expression, reduced pathological aggregation, increased survival of dopaminergic neurons in the substantia nigra, and improved both motor and anxiety-like behaviors (53)