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The excessive activation of immune cells in the brain produces inflammatory molecules TNF-, IL-1 and IL-6, worsening damage to dopamine-producing neurons and speed up PD development ( The management of PD relies heavily on anti-inflammatory effects, highlighting the necessity for deciphering the mechanism of oxidative stress substantially driving disease progression

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Researchers have similarly found that all patients living with COVID-19 showed significantly higher levels of miRNA-181a expression, indicating the pathogenic function and prognostic significance of miRNA-181 in patients with comorbid ALL and COVID-19 [153] (Fig