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Data availability This manuscript does not have data that need to be deposited in a public database

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Piperine: Piperine is the active compound in black pepper

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The activity of caspase 3, but not caspases 1, 8, or 9, is increased in the BSO-treated E47 cells, and damage to mitochondria appears to play a role in the CYP2E1- and BSO-dependent toxicity, because mitochondrial membrane potential is found to be decreased in the process [124]

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