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In addition to using genetically engineered bacteria as drug delivery carriers, extracellular vesicles (EVs), especially exocrine bodies, originate from cells through exocytosis and are absorbed by target cells, which can transmit biological signals or even deliver drugs between local or distant cells (47)

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Subsequently, the BMDMs were induced with interleukin-4 (IL-4, 40 ng/mL) or lipopolysaccharide (LPS, 100 ng/mL, Sigma-Aldrich, St

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