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Several key factorsincluding the pharmacologic targets of the drugs, host metabolism, genetic variability, and drug-drug interactionscontribute to the overall toxicity profile of oral agents

For instance, oxidative stress may lead to, and be caused by, mitochondrial dysfunction which leads to the release of mitochondrial DNA and other mitochondrial components into the cytosol, triggering cell senescence, thereby enhancing inflammation via activation of the SASP, which, in turn, may promote localized tissue fibrosis

2 Add Solvent Slowly introduce 12 mL of bacteriostatic water along the inside wall of the vial

Medical Science Monitor, 17(12), CR677-CR682