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10.1136/gutjnl-2012-303839 132 ShinS

Low levels have been associated with irritability, low energy, and mood fluctuations

Metformin affects the gut microbiota composition, which in turn may influence its therapeutic effects

Key supporting research from 2024-2025 includes a July 2024 paper in Inflammopharmacology (PMID: 38980576) linking BPC-157 to stress response mechanisms, a January 2025 HSS Journal systematic review on neuromuscular applications (PMID: 40756949), and a 2025 Journal of Neuropsychiatry and Clinical Neurosciences perspectives paper positioning BPC-157 as an emerging therapeutic for CNS disorders