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The increased MAO-A levels in chronic social stress result in decreased serotonin and dopamine release, playing a role in depression from chronic stress.[ref] MAO-A, MAOIs, and Tyramine: MAO enzymes, particularly MAO-A , are involved in the breakdown of tyramine, a naturally occurring amine found in certain foods

These changes may lead to a range of changes across dopamine and serotonin neurotransmitter systems across a wide range of brain networks (88, 124, 125, 129)

The results indicated that KMO inhibition was able to reduce significantly the extent of leukocyte infiltration into the brain as well as the histological assessment of neuronal death

Surgery is also recommended less frequently, and given based on evidence-based risk and patient preference, rather than an arbitrary number of episodes