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In vitro / animal: the large majority of the literature fibroblast collagen synthesis, glycosaminoglycan and proteoglycan expression in rat wound models, gene-expression profiling via the Broad Institute Connectivity Map, rodent and rabbit wound models

While analogs with reduced IGFBP affinity show increased potency in vitro, careful pharmacokinetic work has shown that such analogs are actually cleared more rapidly than native IGF-1 after parenteral administration in vivo, because the binding proteins that inhibit activity also serve as a circulating reservoir that prolongs systemic presence

How to reconstitute peptides and administer them properly includes needle selection based on body composition

They are easily accessible and dont require needles or syringes