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Apoptosis was also confirmed by the accumulation of the proapoptotic proteins p53 and p27, and by cleavage of full-length PARP (poly (ADP-ribose) polymerase), primarily in Ru II -02 at 24 h of treatment

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5.1 Neuronal death: the core pathological phenotype The pathological definition of PD, as established by the International Parkinson and Movement Disorders Society (IPMDS) Task Force, centers on the core clinical motor syndrome of parkinsonism, accompanied by the degeneration of DA neurons and the formation of LBs characterized by -syn deposition (Berg et al., 2014)