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Additionally, some studies have small sample sizes or lack sufficient power to detect meaningful clinical differences, while others fail to control for confounding factors such as concurrent antioxidant therapy, severity of illness, and pre-existing nutritional deficiencies

It typically results from inadequate insulin secretion because of dysfunction of the insulin-secreting pancreatic beta cells

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However, despite the fact that many experiments have shown statistically significant geroprotective and neuroendocrine effects of Epitalon, resulting from its antioxidant, neuroprotective, and antimutagenic effects, its mechanism of action remains unclear